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The aim of this article is to present a design method for creating a technological artifact, understood as a digital environment, which host a digital museum that supports an optimized knowledge organization system based on human rather than subject-based aspects. Thus, the suggestion of this study is that digital museum environments be organized considering human aspects such as the reason for information search, cognitive functions and meaningful experiences, influence of societal and technological aspects on knowledge growth, etc. This study is justified since, according to the strategic map of museums, the issues related to preservation, diffusion and access, as well as social function, education and research comprise at least 50% of the museum's strategic actions. Contemporary museology has faced challenges, leading to new study perspectives, without concern for specific themes and privileging diverse contributions, as well as focusing on themes that go beyond communication processes and museum spaces.In general, the organizational structure of information appropriation in different contexts and media in digital environments of museological entities demands a re-contextualization of the museum object when it is transformed from the physical to the digital context. In this process, the interface is the locus where the interaction of the individual with the museum objects and the knowledge organization content of this digital environment take place. This interface should, therefore, be based on the principles of Design Science and IHC to provide quality solutions and innovations, pointing out new perspectives for communication and mediation of museum objects.